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By selectively inhibiting NNMT, 5-Amino-1MQ has demonstrated the ability to raise intracellular NAD+ and SAM levels, activate SIRT1, reduce adipocyte differentiation, decrease lipid accumulation, and produce significant fat mass reduction without caloric restriction in preclinical rodent models

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Researchers should consider whether a peptide mechanism of action could theoretically worsen the specific immune pathways that are already overactive in SLE